The first season takes place in the fall of 2015 with Eva Kviig Mohn as the main character. The storyline deals with Eva's difficult relationship with her boyfriend Jonas and the themes of loneliness, identity, belonging, and friendship.

The second season is focused on Noora Amalie Sætre. It is about her relationship with William and deals with issues of friendship, feminism, eating disorders, self-image, violence, sexual violence, and the contemporaneous refugee crisis concerning Norwegian democracy.

The fourth and final season has Sana Bakkoush as the main character. The season deals with the Islamic religion, forbidden love, cyberbullying, friendship, and the Norwegian "russ" celebratory period.

The third season is focused on Isak Valtersen. The season deals with Isak's burgeoning relationship with Even Bech Næsheim and is principally a coming-out story that deals with issues of love, sexual identity, authenticity, mental illness, religion, and friendship.

SKAM Austin follows the lives of students at Bouldin High.

SKAM Austin follows Megan’s life as a sophomore at Bouldin High.