Low-level bureaucrat Sam Lowry escapes the monotony of his day-to-day life through a recurring daydream of himself as a virtuous hero saving a beautiful damsel. Investigating a case that led to the wrongful arrest and eventual death of an innocent man instead of wanted terrorist Harry Tuttle, he meets the woman from his daydream, and in trying to help her gets caught in a web of mistaken identities, mindless bureaucracy and lies.

Before the Seavers leave for a family vacation to San Francisco, they drop off their pets — Chance, an adventurous American bulldog; Shadow, a wise golden retriever; and Sassy, a cautious cat — at a friend's ranch. But when the animals start to worry that they've been left for good, the three embark together on a treacherous and thrilling journey to find their way back home through the California wilderness.

Larry Donner, an author with a cruel ex-wife, teaches a writing workshop in which one of his students, Owen, is fed up with his domineering mother. When Owen watches a Hitchcock classic that seems to mirror his own life, he decides to put the movie's plot into action and offers to kill Larry's ex-wife, if Larry promises to murder his mom. Before Larry gets a chance to react to the plan, it seems that Owen has already set things in motion.

When the pets accidentally get separated from their vacationing owners, Chance, Shadow, and Sassy navigate the mean streets of San Francisco, trying to find their home across the Golden Gate Bridge. But the road is blocked by a series of hazards, both man and beast.

FBI Agent Will Graham, who retired after catching Hannibal Lecktor, returns to duty to engage in a risky cat-and-mouse game with Lecktor to capture a new killer.

A rash of bizarre murders in New York City seems to point to a group of grotesquely deformed vagrants living in the sewers. A courageous policeman, a photojournalist and his girlfriend, and a nutty bum, who seems to know a lot about the creatures, band together to try and determine what the creatures are and how to stop them.