Never Give a Sucker an Even Break is a 1941 film about a man who wants to sell a film story to Esoteric Studios. On the way he gets insulted by little boys, beaten up for ogling a woman, and abused by a waitress. W. C. Fields' last starring role in a feature-length film.

Dr. Paul Carruthers is frustrated because he thinks his employers, Mary Heath and Henry Morton, have cheated him out of the company's profits. He decides to get revenge by altering bats to grow twice their normal size and training them to attack when they smell a perfume of his own making. He mixes the perfume into a lotion, which he offers as a gift to Mary and Henry. When they turn up dead, a newspaper reporter decides to investigate.