Marty, a butcher who lives in the Bronx with his mother is unmarried at 34. Good-natured but socially awkward he faces constant badgering from family and friends to get married but has reluctantly resigned himself to bachelorhood. Marty meets Clara, an unattractive school teacher, realising their emotional connection, he promises to call but family and friends try to convince him not to.

Dr. Bock, the chief of medicine at a Manhattan hospital, is suicidal after the collapse of his personal life. When an intern is found dead in a hospital bed, it appears to Bock to be a case of unforgivable malpractice. Hours later, another doctor, who happens to be responsible for another case of malpractice, is found dead. Despondent, Bock finds himself drawn to Barbara, the daughter of a comatose missionary.