Seven years after the events of the third season, Maeve and Caleb begin to suspect that Hale and The Man in Black are trying to regain control of the human race. Meanwhile, Bernard returns from The Sublime. A young writer, Christina, begins to question the nature of her reality.

Season two roars back into action with Ash leaving his beloved Jacksonville and returning to his hometown of Elk Grove, Michigan. There, he confronts Ruby. The former enemies have to form an uneasy alliance as Elk Grove soon becomes the nucleus of evil.

A strange doorway appears in the basement of a furniture showroom.