Walter Lee Younger is a young man struggling with his station in life. Sharing a tiny apartment with his wife, son, sister and mother, he seems like an imprisoned man. Until, that is, the family gets an unexpected financial windfall.

A blind, uneducated white girl is befriended by a black man, who becomes determined to help her escape her impoverished and abusive home life.

In the early 1900s, the fictional Catfish Row section of Charleston, South Carolina serves as home to a black fishing community. Crippled beggar Porgy, who travels about in a goat-drawn cart, loves the drug-addicted Bess, who lives with stevedore Crown, the local bully.

As Kenya's Mau Mau uprising tears the country apart, former childhood friends Kimani (Sidney Poitier), a native, and Peter (Rock Hudson), a British colonist, find themselves on opposite sides of the struggle in this provocative drama. Though each is devoted to his cause, both wish for a more moderate path -- but their hopes for a peaceful resolution are thwarted by rage, colonial arrogance and escalating violence on both sides.

An American submarine leaves Tierra Del Fuego, and one of its crew has secretly brought aboard a container full of poisonous snakes which escape storage and bite key personnel on the submarine, causing an accident that cripples the vehicle so that it drops to the bottom of the Southern Ocean. Worse still, the snakes are still at large on the submarine and complicate the efforts of the crew to escape the sunken vessel.