An elderly, venerable priest goes over the side of the Golden Gate Bridge and everyone except his nurse, Sister Benecia, believes that it was suicide. Sister Benecia finally manages to convince the police department to assign a detective, the cynical, irascible Paul Silver, to investigate. The "Mad Nun" and the "Mad Cop" become a formidable investigative team -- and much, much more.

Someone is shooting the residents of a mountain resort town. Sheriff McNeill (Andy Griffith) must figure out the connection that links the victims and find the sniper before he (or she) kills again, and before the town council relieves him of duty.

On the day before she retires, a teacher discovers that a student she had flunked ten years previously is out to kill her.

A break-in and sabotage attempt occurs at a top secret research institute and the culprit is cornered and captured. The problem is that he's been badly injured and claims to have lost his memory entirely. A cat-and-mouse game ensues between investigator Tuxan, the mystery intruder Welles and the people who sent him on the mission.