After a disastrous defeat at the 2018 World Cup, Japan's team struggles to regroup. But what's missing? An absolute Ace Striker, who can guide them to the win. The Japan Football Union is hell-bent on creating a striker who hungers for goals and thirsts for victory, and who can be the decisive instrument in turning around a losing match...and to do so, they've gathered 300 of Japan's best and brightest youth players. Who will emerge to lead the team...and will they be able to out-muscle and out-ego everyone who stands in their way?

When apathetic gamer Nagi agrees to join his rich classmate Mikage in soccer, their partnership leads to the famous Blue Lock program — and to changes.

——赌上一切去挑战。上吧，才能的原石们啊。改变时代的，是我们“Blue Lock（蓝色监狱）”——
为了培育出带领日本获得W杯优胜的射手，日本足联设立了“Blue Lock（蓝色监狱）”计划。
被邀请参与计划的是300名高中生。
而且全员都是FW（前锋）。
身处一旦被淘汰就会失去将来加入日本足球代表资格的极限状态下，被选中的才能的原石们逐渐觉醒了身为射手的Ego。
时而踢落他人，时而凭自身的进化从严苛的选拔中生存下来的35人。
跨越了盘旋着Ego的、狂热的生存战的他们，赌上“Blue Lock（蓝色监狱）”计划的存续，向与U-20日本代表展开的史上最疯狂的决胜赛（Big Match）发起挑战！
现在，为了将自己的Ego铭刻于世，为了亲手改变命运，史上最炽热的战斗<比赛>即将开始。