A story set in the mid-1800's about a young doctor who has been trained in Western-style medicine and a young samurai who is trying to live up to the old traditions of his class and culture. The story is actually based upon real people - the doctor, Ryo-an, was Tezuka's great grandfather.

The manga series was adapted to anime by Madhouse Studios and premiered in Japan on NTV on April 4, 2000.

On the night of his 30th birthday, one man’s dreams of wielding magic come true after he unexpectedly passes away. He wakes as Sion, a young child in another world. He and his elder sister, Marie, are the children of a lower-class noble family who govern their region. After receiving conflicting messages from their father, Sion and Marie set out on an adventure to uncover the magic.

Forty years ago, the minds of Paradigm City's inhabitants were wiped clean of all recollections of the past. Now, ruled by a powerful corporation and cut off from the rest of the world by desolate wastelands, Paradigm has become a virtual police state where Negotiators like Roger Smith keep the wheels of progress, commerce, and society turning.

Five years after the death of the Emperor of Marmo in the War of Heroes, Parn is now the Free Knight of Lodoss, he and his old allies now famous through the land. However, the Emperor's right-hand-man, Ashram, seeks the Scepter of Domination to re-unify Lodoss under his former leader's banner. Meanwhile, beyond his attempts at conquest lies a more sinister force beginning to set the stage for the resurrection of the goddess of death and destruction...

A large scale catastrophe is occurring across the planet. Ability users are discovered after the appearance of a mysterious fog, apparently having committed suicide, so the Armed Detective Agency sets out to investigate these mysterious deaths. The case seems to involve an unknown ability user referred to as "Collector," a man who could be the mastermind behind the incident.
Trust and courage are put to the test in order to save the city of Yokohama and ability users across the world from the grip of Collector where the Armed Detective Agency forms an unlikely partnership with the dangerous Port Mafia.

Shimazu Toyohisa is a real-life samurai who fought in the pivotal Battle of Sekigahara. In his dying moments, Shimazu is transported to a world of magic with other famous warriors throughout history. These warriors are forced to fight each other in an endless battle.

In 1948 Tokyo, just right after the war, Kanna Kusakabe had just become a second-year at a high school when she meets the new language teacher, Akihiko Chuzenji. Mysterious supernatural things keep happening around Kanna. Once again today, Kanna is going to open the doors to the library prep room to seek help from the surly Chuzenji-sensei who is waiting inside.

自古妖魔侵入人类的世界，化作人形并以吞食人类的内脏为生，对妖魔束手无策的人类唯有求助于身背巨剑的女性战士们。因为战士们是由于体内混合了妖魔的血肉才得到超人的力量，所以人类同样将她们视为异类，一方面依靠着她们斩杀妖魔，一方面畏惧并排斥着她们，并将她们称为“Claymore（大剑）”。 当妖魔的出现打破了一个普通山村的平静生活，万般无奈的村长只好求助于大剑组织。一位面容冷酷的战士接受委托来到这里，由此拉开了这场波澜壮阔的故事序幕。

Suzu is a 17-year-old high-school student living in a rural town with her father. Wounded by the loss of her mother at a young age, Suzu one day discovers the massive online world "U" and dives into this alternate reality as her avatar, Belle. Before long, all of U's eyes are fixed on Belle, when, suddenly, a mysterious, dragon-like figure appears before her.

The theft of the Greater Grail from Fuyuki City leads to a splintered timeline in which the Great Holy Grail War is waged on an unprecedented scale.

Mitsumasa Kido discovers a misterious baby in the himalayas whom he adopts as his grandaughter. 16 years later, Saori Kido is a young girl troubled by her mysterious powers. She is saved by Seiya from an assassin sent to kill her. Saori then learns she is the reincarnation of the Goddess Athena with Seiya being one of her Saints sworn to protect her. Upon learning of her destiny, she heads to the Sanctuary to rebel against the Pope's murderous plot.

Paradise—a legend, a myth, and a hopeless dream in a world that has become a wasteland. It is not meant for everyone, only the wolves thought to be extinct yet still roam the lands. When the Flower Maiden awakens, the path to the end will open.

Kiba, a lone white wolf, wanders into a poverty stricken city on a quest. The scent of Lunar Flowers and the will to find Paradise is all he has. Along the way, he runs into other outcast wolves—Tsume, Hige, and Toboe, each with their own story and troubles. Fate bringing them together, they seek out the Flower Maiden, Cheza, and their way to Paradise. But, doing so is no simple matter. Up against a world that fears them and a man with mysterious abilities, their journey is overrun with challenges and worse—sacrifices. With limited time, they must fight to protect Cheza against everyone who seeks her and discover the hidden path to their destiny.

Moshimo, Japan. The annual fireworks festival is about to take place and a group of schoolboys, arguing over whether they are round or flat when viewed from different angles, set out to find it out.

Five children save the life of a dog-like alien while at a self-run summer camp. He attempts to reward them by taking them to an alien colony on the Moon. Events take a turn for the worse when his report on that attack that injured him causes passage from the Moon to the Earth to be banned, and children are stranded in space. The children need to find a way back home before camp ends and their parents discover that they are missing. They also have to avoid the poachers that injured their alien friend, and now seem to be stalking them all.

Atsushi Nakajima was kicked out of his orphanage, and now he has no place to go and no food. While he is standing by a river, on the brink of starvation, he rescues a man whimsically attempting suicide. That man is Osamu Dazai, and he and his partner Kunikida are members of a very special detective agency. They have supernatural powers and deal with cases that are too dangerous for the police or the military. They're tracking down a tiger that has appeared in the area recently, around the time Atsushi came to the area. The tiger seems to have a connection to Atsushi, and by the time the case is solved, it is clear that Atsushi's future will involve much more of Dazai and the rest of the detectives!

One day, New York City as we know it vanished overnight into a mysterious fog. Now known as Hellsalem's Lot, it has become a place where another world beyond imagining is connected to our reality. The balance within this new world is protected by a secret society known as Libra. Leo, a journalist and photographer who arrives in the city, is unexpectedly recruited to join their ranks.

Satoru Fujinuma is a struggling manga artist who has the ability to turn back time and prevent deaths. When his mother is killed he turns back time to solve the mystery, but ends up back in elementary school, just before the disappearance of his classmate Kayo.

It has been 800 years since the incredibly fast and powerful gods of battle known as the Idaten had sealed away the demons after an intense battle. Now, that battle is just considered a myth or a fairytale. While the current generation of Idaten who have never even had to fight are enjoying their peaceful lives, someone awakened the demons once again! Armed forces, ingenuity, politics, and intrigue. If you've got it, use everything you can! This three-way battle royale with no rules and no limits is about to begin!!

Tohru Honda is 16 year old orphaned girl who gets invited to live in the house of her classmate, the handsome boy Sohma Yuki, and his cousins, 16 year old Kyo and 27 year old Shigure. However, these young men and parts of the rest of their family (both close and distant) hold a curse; if they are hugged by the opposite gender, they transform into animals of the Chinese Zodiac. Everyday is an adventure for sweet Tohru, as she gets to know everyone in the large family better (especially Yuki and Kyo), in both common and bizarre situations. But, the Sohma Family curse is certainly no laughing matter... it also holds horrible cruelty and heartbreak.

Akira Tachibana is a soft-spoken high school student who used to be a part of the track and field club but, due to an injury, she is no longer able to run as fast as she once could. Working part-time at a family restaurant as a recourse, she finds herself inexplicably falling love with her manager, a divorced 45-year-old man with a young son.

Despite the age gap, Akira wholeheartedly embraces his mannerisms and kind nature, which is seen as spinelessness by the other employees, and little by little, the two begin to understand each other. Although unable to explain why exactly she is attracted to him, Akira believes that a concrete reason is not needed to truly love someone. On a rainy day, she decides to finally tell her manager about how she feels... but just how will he react?