The film tells the story of two good friends who live together, Andrew, an agoraphobic travel agent who works from his home, and Dave, a loser who works in an office where he is treated with contempt. Just when it seems things can't get any worse for the two, the entire world outside of their house disappears and is replaced with an endless white void.

A color-blind psychiatrist is stalked by an unknown killer after taking over his murdered friend's therapy group and becomes embroiled in an intense affair with a mysterious woman who may be connected to the crime.