Dr. Bock, the chief of medicine at a Manhattan hospital, is suicidal after the collapse of his personal life. When an intern is found dead in a hospital bed, it appears to Bock to be a case of unforgivable malpractice. Hours later, another doctor, who happens to be responsible for another case of malpractice, is found dead. Despondent, Bock finds himself drawn to Barbara, the daughter of a comatose missionary.

The teachers and students of a countryside elementary school are thrown into a panic when an air raid siren goes off, warning them of a imminent nuclear attack.

Sabrina Fairchild, a chauffeur's daughter, grew up at the Long Island estate of the wealthy Larrabee family enchanted with their sparkling world of privilege and wealth, but she's especially enamored of younger son David, a charming playboy. After the once plain Sabrina returns from a sojourn in Paris transformed into a glamorous young woman, she at long last catches David's eye. In a calculated effort to manipulate David away from her and into a more financially advantageous marriage, formidable older brother Linus devises a plan to keep them apart.

When the bumbling Lieutenant Frank Drebin investigates events following the shooting of his partner, he stumbles upon an attempt to assassinate Queen Elizabeth II.