In Cameron, a group of hunters is attacked by a wild animal, and Charlie Cowley survives, but sees his brother Scott dying. Seven years later, his teenage nephew Derek Cowley steals the key of his stepfather's cabin in the isolated Fire Road 13, and travels with four classmates and his friend Sam to spend the weekend having a party with booze and sex. However, they are attacked by a Beast that kills his friends in a sadistic way. Sam and Derek survive, and they suspect that his stepfather, Mitchell Toblat, is a werewolf. When Charlie meets Derek and Sam, they decide to collect evidence to prove that Mitchell is the Beast and kill him, but Mitchell discovers their plot and chases the trio.

Charlie is a kid whose archeologist father has made several discoveries while exploring a cave in Colorado. However, Charlie makes a discovery of his own -- the spirit of a long-dead explorer has come back to haunt him until his remains can be recovered and finally buried in a proper place. But Charlie can't manage this task on his own, with his old man being too busy with his work to aide the restless soul. What's a supernaturally-afflicted lad like him to do?