A former safecracker makes a living as a taxi driver but continues to be haunted by her past. One day she chances upon an aspiring singer, who is a spitting image of herself back in the day. Together, the two women plot to steal money from gangsters.

Cha Moo Hyuk is a man who was adopted by an Australian family but treated cruelly and then abandoned at a young age. By chance, he meets Song Eun Chae, a fashion coordinator dedicated to her employer, singer Choi Yune. Their meeting will have implications for the rest of Cha Moo Hyuk's life as a devastating turn of events leads him to delve into his past, and ultimately find happiness.

Lee Gyu Won is the daughter of one of the top three maestros of pansori and is also a gayageum protégé herself. Following her grandfather’s wishes for her to study the gayageum, she enrolls as a major of gugak, or traditional Korean music. Lee Shin is unfriendly, yet a clever student in the Applied Music Department who also is the famed vocalist and talented guitarist of the handsome band named The Stupid. With charming looks equal to those of a handsome character in a romance comic and a cold, taciturn personality, he thinks gugak is boring and belittles it. As the vocalist Lee Shin and Gayageum Protégé Lee Gyu Won passionately confront each other to champion their respective music, they soon fall in love.

A timid and extravagant bank clerk, Dae-ho is considered inefficient at his workplace. As he tries to be recognized by his superior, his efforts only cause more bad situations. But he has an explosive energy that nobody knows about. One day, after yet another day of suffering at work, he goes to a wrestling gym to persuade its owner to become his bank’s client. And, by accident, he starts to learn how to wrestle. From then, he starts to live a new life. And his personality starts to change…

In the dead of night, a body donated for organ transplants mysteriously disintegrates into ashes. Soon after, five recipients, given a heart, corneas, lungs, liver, and kidneys, begin to develop supernatural powers. A teenage girl gains immense strength, a hipster manipulates electromagnetic waves, a novelist summons powerful gusts, a factory manager can heal others, and a woman discovers a strange, still-unidentified ability. Together, they form a reluctant but heroic team known as "HI-FIVE." But they aren't the only ones transformed. A cult leader who received the donor’s pancreas gains the terrifying power to drain life energy and sets his sights on stealing the abilities of HI-FIVE to achieve godlike domination.