The Stooges are private detectives in the Old West trying to help a girl recover an IOU from a bad guy. Their attempts to steal the IOU from the villain's wallet and then from a safe meet with problems until Curly, who goes berserk whenever he sees a mouse, knocks out all the bad guys.

The Stooges become trainers of Bustoff, a champion wrestler. The big boss has a lot of money bet on Bustoff and orders the boys to take good care of him. Instead they accidentally knock him out and Curly must disguise himself as Bustoff and wrestle in his place. The match doesn't go very well until Curly smells "Wild Hyacinth" perfume on a lady fan at ringside. This drives him crazy and he knocks out his opponent and half the people in the stadium.

The stooges are down and out. With a cop chasing them, they flee into an artists studio where they are mistaken for students. The cop continues to hunt for them and they use a variety of disguises and tactics to elude him. A wild clay throwing fight ends the film.

A trio of amateur film makers try to persuade a group of studio executives to exhibit their new movie.