In Los Angeles, Max Carlyle makes a good living directing commercials and has a happy home life with his wife, Mimi, and two children. When Carlyle travels to New York City to visit his friend Charlie, who has been diagnosed with AIDS, he has repeat run-ins with a beautiful woman, Karen, and eventually sleeps with her. Though he goes home the next day and doesn't return until a year later, Carlyle's infidelity still lingers.

A production company begins casting for its next feature, and an up-and-coming actress named Rose tries to manipulate her filmmaker boyfriend, Alex, into giving her a screen test. Alex's wife, Emma, knows about the affair and is considering divorce, while Rose's girlfriend secretly spies on her and attempts to sabotage the relationship. The four storylines in the film were each shot in one take and are shown simultaneously, each taking up a quarter of the screen.