Rayne, a half-human half-vampire warrior, is in the America's 1880's Wild West to stop the vampired Billy the Kid and his posse of vampire cowboys.

Rayne fights against the Nazis in Europe during World War II, encountering Ekart Brand, a Nazi leader whose target is to inject Adolf Hitler with Rayne's blood in an attempt to transform him into a dhampir and attain immortality.

A man named Farmer sets out to rescue his kidnapped wife and avenge the death of his son – two acts committed by the Krugs, a race of animal-warriors who are controlled by the evil Gallian.