In the dead of night, a body donated for organ transplants mysteriously disintegrates into ashes. Soon after, five recipients, given a heart, corneas, lungs, liver, and kidneys, begin to develop supernatural powers. A teenage girl gains immense strength, a hipster manipulates electromagnetic waves, a novelist summons powerful gusts, a factory manager can heal others, and a woman discovers a strange, still-unidentified ability. Together, they form a reluctant but heroic team known as "HI-FIVE." But they aren't the only ones transformed. A cult leader who received the donor’s pancreas gains the terrifying power to drain life energy and sets his sights on stealing the abilities of HI-FIVE to achieve godlike domination.

The surface of the Earth is under attack, thousands of people are killed in this unprovoked attacked. The cause, Princess Dragonmon and her army of monsters have decided to invade. Princess Dragonmon is an alien whose race has been hiding under us for centuries waiting to attack at the time is right. A doctor has been preparing for something like this and turns his assistant Rayma into the cyborg hero known as Inframan. Now only Inframan stands between the Earth and Princess Dragonmon but when a close friend is captured and brainwashed, can she be stopped with this inside man feeding her info?