In the mid-19th century, Senator William J. Tadlock leads a group of settlers overland in a quest to start a new settlement in the Western US. Tadlock is a highly principled and demanding taskmaster who is as hard on himself as he is on those who have joined his wagon train. He clashes with one of the new settlers, Lije Evans, who doesn't quite appreciate Tadlock's ways. Along the way, the families must face death and heartbreak and a sampling of frontier justice when one of them accidentally kills a young Indian boy.

Londoner Harry Fabian is a second-rate con man looking for an angle. After years of putting up with Harry's schemes, his girlfriend, Mary, becomes fed up when he taps her for yet another loan.