In the dead of night, a body donated for organ transplants mysteriously disintegrates into ashes. Soon after, five recipients, given a heart, corneas, lungs, liver, and kidneys, begin to develop supernatural powers. A teenage girl gains immense strength, a hipster manipulates electromagnetic waves, a novelist summons powerful gusts, a factory manager can heal others, and a woman discovers a strange, still-unidentified ability. Together, they form a reluctant but heroic team known as "HI-FIVE." But they aren't the only ones transformed. A cult leader who received the donor’s pancreas gains the terrifying power to drain life energy and sets his sights on stealing the abilities of HI-FIVE to achieve godlike domination.

Kim Sun-woo is an enforcer and manager for a hotel owned by a cold, calculative crime boss, Kang who assigns Sun-woo to a simple errand while he is away on a business trip; to shadow his young mistress, Hee-soo, for fear that she may be cheating on him with a younger man with the mandate that he must kill them both if he discovers their affair.

A young man believes that his country's leaders are actually toxic reptilian aliens sent down to launch a takeover of his beloved Earth. So he decides to abduct them and force the truth out on camera in his basement that doubles as a film studio and torture chamber.

Brothers Jae-pil and Sang-gu move into their dream rustic-style house in the woods. When unwanted visitors arrive and awaken a sealed evil spirit in the basement, a dark aura begins to envelop the house.

With no clue how he came to be imprisoned, drugged and tortured for 15 years, a desperate man seeks revenge on his captors.