Hitman Martin Blank becomes a moving target after he rebuffs a fellow assassin's invitation to form a union. On the advice of his quirky assistant and neurotic psychiatrist, Martin begrudgingly heads out to Grosse Pointe, Michigan for his ten-year high school reunion, where he soon comes across the woman he jilted on prom night.

Gib, a beer-guzzling slob, and Alison, an uptight Ivy-Leaguer, are an unlikely duo stuck together on a cross-country trip during Christmas break. At first they get on each other's nerves but, as time passes, they find their divergent natures complement each other. Now they need to realize what they've already found before it's too late.