Jimmy Rabbitte, just a thick-ya out of school, gets a brilliant idea: to put a soul band together in Barrytown, his slum home in north Dublin. First he needs musicians and singers: things slowly start to click when he finds three fine-voiced females virtually in his back yard, a lead singer (Deco) at a wedding, and, responding to his ad, an aging trumpet player, Joey "The Lips" Fagan.

Billy Hayes is caught attempting to smuggle drugs out of Turkey. The Turkish courts decide to make an example of him, sentencing him to more than 30 years in prison. Hayes has two opportunities for release: the appeals made by his lawyer, his family, and the American government, or the "Midnight Express".