Season three is driven by June's resistance to the dystopian regime of Gilead and her struggle to strike back against overwhelming odds. Startling reunions, betrayals, and a journey to the terrifying heart of Gilead force all characters to take a stand, guided by one defiant prayer: "Blessed be the fight."

Offred must navigate between Commanders, their cruel Wives, domestic Marthas, and her fellow Handmaids – where anyone could be a spy for Gilead – with one goal: to survive and find the daughter who was taken from her.

Recent arrivals Jenny and Tim experience marital turmoil when Jenny finds herself attracted to Marina, the alluring owner of local cafe and gathering place The Planet; Tina struggles to become pregnant through artificial insemination but a miscarriage and Bette's infidelity bode ill for their seven-year relationship; tennis pro Dana stays in the closet but falls for sous chef Lara; Shane deals with her growing fame; Alice looks for love.

Tina reveals that she is pregnant again as she begins dating heiress Helena and Bette's life spins out of control; Shane and Jenny each begin dating sexy deejay Carmen and discover that their roommate Mark is secretly videotaping them for a documentary project; Kit buys The Planet and takes over as proprietor; Alice and Dana begin dating but conceal the relationship at first.

A sexy nightclub owner, Barb Wire moonlights as a mercenary in Steel Harbor, one of the last free zones in the now fascist United States. When scientist Cora Devonshire wanders into Barb's establishment, she gets roped into a top-secret government plot involving biological weapons. Soon Barb is reunited with her old flame Axel Hood, who is now Cora's husband and a guerrilla fighter, resulting in plenty of tense action.