On the mystic island of Lemuria, the cult of Ubasti seek the Egyptian Princess Nadji to sacrifice so that their goddess Ossana, whose soul resides in Nadji's body, may be resurrected by Black Magic. Nadji is located in the Far East port of Suva, but shielded by the White Magical powers of Frank Chandler, an American raised by Eastern mystics who is also known as Chandu. When Chandu takes a voyage alone, however, the evil Voice of Ubasti is able to magically spirit her to Lemuria, where Black Magic reigns supreme. Chandu sets out in pursuit with his sister Dorothy, niece Betty and nephew Bob; but, shipwrecked on the magic island, Chandu finds his family also held prisoner for sacrifice while he is plunged into an endless maze of caverns beneath the evil temple, where both his mortal and magical strength seem rendered useless.

An old rocking chair makes a story out of Old Boggs, his daughter Madge, and her boyfriend Jack.

The Stooges are pest exterminators who drum up business by planting vermin in a ritzy mansion where a party is going on. They are hired, but must pose as guests to work unobserved. They ruin a piano and generally make a mess of the party, but the hostess passes them off as vaudeville comedians and they are invited to join the guests on a fox hunt.