Thankam follows the story of Muthu and Kannan, two gold agents from Thrissur, known as the gold capital of India. As they travel across Kerala and Tamil Nadu, delivering consignments of gold, their lives take a dark turn when a routine trip leads to unexpected complications.

After losing his job, Aby and his wife, Priya, move back to the latter's family estate in Kerala. However, things go from bad to worse for the couple as they encounter a new set of challenges..