Athena receives the visit of Phoebus Abel, her older brother and God of the Corona. He informs her that he has come to destroy humanity as punishment for their corruption, just as it was done in ancient times. He dismisses Seiya and the Bronze Saints, as she will now be guarded by Abel's three Corona Saints, Atlas of Carina, Jaow of Lynx and Berenike of Coma Berenices, and the five resurrected Gold Saints who died in the Sanctuary battle: Saga of Gemini, Deathmask of Cancer, Shura of Capricorn, Camus of Aquarius and Aphrodite of Pisces. When Athena rebels against Abel's plan, he attacks her, sending her soul to Elysion, the final resting place from which there is no return. The Bronze Saints immediately rush to the Sanctuary to save her and ultimately overcome Abel.

There is a small town somewhere in Japan, which is surrounded by nature. In this town, there is a large and gorgeous school, Otobashi Gakuen; which was founded to make the students familiar with nature. This story starts off with Kurusugawa Himeko. She is a normal student who goes to Otobashi Gakuen. She leads bright and enjoyable school days with her two friends, Himekawa Chikane and Oogami Souma. Chikane is the only daughter of a distinguished family. She excels at both academics and sports. She is also kind and beautiful, making her very popular among the other students. Oogami Souma is Himeko’s childhood friend. He has problems expressing his emotions directly, but he is very sincere. On Himeko's 16th birthday, a dark moon blocks out the sun, and the Orochi come forth to destroy the world. But why are they targetting Himeko...?

Ryu and Ken travel the world to become better fighters and learn new techniques. During their journey, they find themselves caught up in a conspiracy of the mysterious Shadowlaw.

The adventures of Leo, a young lion cub who becomes king of the jungle when his father, the previous king of the jungle is killed by a human hunter.

A story set in the mid-1800's about a young doctor who has been trained in Western-style medicine and a young samurai who is trying to live up to the old traditions of his class and culture. The story is actually based upon real people - the doctor, Ryo-an, was Tezuka's great grandfather.

The manga series was adapted to anime by Madhouse Studios and premiered in Japan on NTV on April 4, 2000.

During the Second Year of Ansei (1855) in Edo's Koishigawa are two young men, Manjiro Ibutani and Ryoan Tezuka. Ibutani is a low-ranking samurai who is a gifted swordsman and has a straightforward and strong sense of justice. Tezuka has a more carefree attitude. He has an eye for the ladies, but he is passionate about becoming a doctor. The two opposite characters come of age during the backdrop of the turbulent end of the Tokugawa Period (1600-1868 CE).