Jo & Jo is a coming of age comedy-drama that tells the story of how a few youngsters in a village enjoy their life when the world itself shuts down due to covid19 pandemic and how their life fell apart after an unexpected event happened.

Vinu, who is still grieving over his breakup from five years ago, develops a strong relationship with Anandan, his prospective brother-in-law, but his attempts to resolve Anandan's problems have some unexpected consequences.

Loganathan, a senior cop is asked to mentor Prakash, an academically bright but faint-hearted rookie and this unlikely duo team up to investigate a series of murder cases, and realize all of them are interlinked and that a psychopath serial killer is on the run.