Loganathan, a senior cop is asked to mentor Prakash, an academically bright but faint-hearted rookie and this unlikely duo team up to investigate a series of murder cases, and realize all of them are interlinked and that a psychopath serial killer is on the run.

Vinu, who is still grieving over his breakup from five years ago, develops a strong relationship with Anandan, his prospective brother-in-law, but his attempts to resolve Anandan's problems have some unexpected consequences.

Jo & Jo is a coming of age comedy-drama that tells the story of how a few youngsters in a village enjoy their life when the world itself shuts down due to covid19 pandemic and how their life fell apart after an unexpected event happened.