Seven years on from the events of Monsters, and the ‘Infected Zones’ have spread worldwide. Humans have been knocked off the top of the food chain, with disparate communities struggling for survival. American soldiers are being sent abroad to protect US interests from the Monsters, but the war is far from being won.

A repressed philosophy professor, Dr. John Jorissen, is employed at Ridgemont College, a small liberal arts school in the American Midwest. He teaches an introductory course and is writing a book on renowned Dutch philosopher Baruch Spinoza. Haunted by a long-buried transgression and the sudden return of its victim, he descends into a crisis of guilt, desire, and spiritual reckoning.

When top hitman Joe Flood is diagnosed with a terminal illness, he decides to take matters into his own hands – by taking a hit out on himself. But when the very hitmen he hired also target his ex-girlfriend, he must fend off an army of assassin colleagues and win back the love of his life before it's too late.