Der Bürgerkrieg ist vorbei, daher kehrt das Halbblut Keoma heim. Die Heimat ist verwüstet, überall Leichenberge, die Pockenseuche grassiert und Caldwell, ein Gangster hat in seiner Heimat die Macht übernommen. Er lässt von seiner Bande alles ermorden was noch fliehen will. Mit Hilfe eines ehemaligen Sklaven sagt Keoma Caldwell den Kampf an.

Carlo Antonelli, an engineer from Genoa, gets mugged and decides to take justice into his own hands. At first the muggers seem to get the upper hand, but then he's helped by Tommy, a young robber who takes his side.

Drug use in the city of Rome is at an all-time high. Children score from dealers in front of their schools, mules waltz straight through airport security, and Interpol's main man, Mike Hamilton, is at his wits' end. Fed up to the back teeth with the local police force's incompetence, his only hope is to rely on one of his own men, Fabio, an officer so deep undercover that no-one but Hamilton knows who he really is. Even as Fabio gains the trust of cartel leader Gianni, however, the dealers are edging ever closer to the truth, and when his cover is blown, the hunter becomes the hunted as Fabio finds himself alone in a desperate fight to survive.

1969 film by Enzo G. Castellari