The deranged military and former CIA agent Dean Cage is in a rehab program, trying to forget the traumatic loss of his best friend Scott in Bosnia. When he dates with his girl-friend and Scott's sister, Detective Amy Knight, in a dinning restaurant, he is mistakenly taken as being the CIA agent that is investigating the robbery of the military experiment EX by a man called Sullivan. He is injected with the drug and abducted by the thieves. Amy has six hours to find the also stolen antidote and save Dean's life.

The world is falling into chaos. As he roams a crumbling city, Duncan MacLeod, the Highlander, remembers happier times before the love of his life left... Hopeless and alone, MacLeod finds his way to a band of immortal companions, including his mysterious friend Methos, and a mortal, Watcher Joe Dawson. Together this small group sets out on a quest to find the origin of the first Immortal.