From minor league baseball to big box retail, from funeral homes to alligator farms and even a grade school talent show, Charlie navigates her crime solving existential road-trip with deadpan wit, human empathy, and her signature uncanny lie-detecting ability.

Charlie Cale, a casino cocktail waitress with the ability to detect lies, as she goes on the run after a close friend is murdered. Each episode features a new mystery of the week, with Charlie using her unique skill to solve crimes in different locations while evading a hitman sent after her.