An evil priestess and her twin sister battle for control of a powerful crystal.

In the far east the star of great power is stolen by an ambitious woman, who was jealous of the jungle girl who was sent by the gods, also succeeds in kidnapping her. This mission will only be solved by Santo, the masked man of silver who will have to save the girl and recover the star to return the tranquility to the town.

Bruno Halder a sinister scientist seeking revenge against his brother and niece is resurrected by Waldo his faithful sidekick. Besides his minions of zombies Halder enlists the help of Wolfman, Franquestain, a Vampire, a Mummy and a Cyclops. Once again the survival of mankind is put in the hands of Santo