Manchester, 1976. Tony Wilson is an ambitious but frustrated local TV news reporter looking for a way to make his mark. After witnessing a life-changing concert by a band known as the Sex Pistols, he persuades his station to televise one of their performances, and soon Manchester's punk groups are clamoring for him to manage them. Riding the wave of a musical revolution, Wilson and his friends create the legendary Factory Records label and The Hacienda club.

Steve Coogan, an arrogant actor with low self-esteem and a complicated love life, is playing the eponymous role in an adaptation of "The Life and Opinions of Tristram Shandy, Gentleman" being filmed at a stately home. He constantly spars with actor Rob Brydon, who is playing Uncle Toby and believes his role to be of equal importance to Coogan's.

Matt, a young glaciologist, soars across the vast, silent, icebound immensities of the South Pole as he recalls his love affair with Lisa. They meet at a mobbed rock concert in a vast music hall - London's Brixton Academy. They are in bed at night's end. Together, over a period of several months, they pursue a mutual sexual passion whose inevitable stages unfold in counterpoint to nine live-concert songs.

In late 19th-century England, Jude aspires to be an academic, but is hobbled by his blue-collar background. Instead, he works as a stonemason and is trapped in an unloving marriage to a farmer's daughter named Arabella. But when his wife leaves him, Jude sees an opportunity to improve himself. He moves to the city and begins an affair with his married cousin, Sue, courting tragedy every step of the way.

There's little wonder in the working-class lives of Bill, Eileen, and their three grown daughters. They're lonely Londoners. Nadia, a cafe waitress, places personal ads, looking for love; Debbie, a single mom, entertains men at the hair salon after hours; her son spends part of the weekend with her ex, a man with a hair-trigger temper. Molly is expecting her first baby and its father acts as if the responsibility is too much for him.

Deputy Sheriff Lou Ford is a pillar of the community in his small west Texas town, patient and apparently thoughtful. Some people think he is a little slow and maybe boring, but that is the worst they say about him. But then nobody knows about what Lou calls his "sickness": He is a brilliant, but disturbed sociopathic sadist.