It's the final chapter in the cult classic Class of Nuke'Em High Trilogy, and this time the fate of Tromaville hangs in the balance! Following the destruction of the Nukamama Power Plant by the lovable and horribly mutated toxic squirrel Tromie. Roger Smith (Brick Bronsky) and his half-subhumanoid son Adlai (also played by Brick Bronsky) are working to rebuild Tromaville into a place where human and subhumanoid can live together in peace. Unbeknownst to them, Adlai's twin brother Dick (again played by Brick Bronsky!), kidnapped at birth and raised by the evil Power Clite, has plans to regain contol of the Subhumanoids and turn Tromaville into a nuclear waste dump. In a showdown for the ages, "The Good, the Bad and the Subhumanoid" face off in an explosive sci-fi battle of epic proportions!

Desperate to raise money for the experimental surgery that could restore his blind fiancee's eyesight, Toxie accepts a lucrative job with the evil multinational conglomerate Apocalypse Inc.

Mad scientist Prospero runs away with his blind daughter Miranda to Tromaville, hiding from evil pharmaceutical execs, including his own sister Antoinette who ruined his career after he found the cure against opioid addiction. With the help of a handicapped crack-whore, he releases a massive amount of laxative to whales, while his enemies are on a cruise ship to North Korea. A humongous shitstorm washes the boat away and brings them to Tromaville, where Prospero can now fully realize his ultimate vengeance.

At the Tromaville Institute of Technology's nuclear plant, Prof. Holt has perfected "subhumanoids": living beings without emotions who perform menial tasks. When school reporter Roger Smith meets a beautiful subhumanoid named Victoria, they fall in love and he becomes determined to save her and the school from a giant mutant squirrel, Tromie.