Los Angeles heroin addict Jesse endangers the lives of his childhood friends after he discovers a briefcase full of money from a drug deal gone bad, and returns home with it to Texas. Hoping to turn his life around with his newfound wealth, Jessie endures detox with the support of his friends. However, the gang leader behind the drug deal, along with his cronies, trace Jesse's footsteps to Texas to exact revenge and take back their money.

Marty Mackenzie is an unsuccessful stage actor who takes an interest in private investigating. He takes a job working with Jack Potter, a crusty private eye. They both take a case in Beaver Ridge, a seedy small town where a murder is being planned against a rich gravel pit owner. Marty realizes that private investigating is not as it seemed to be.

Ruby and her husband Claude are a working-class couple who live in suburban Arkansas. As crazy as they are for each other, their relationship is far from harmonious. (The lack of money doesn't help matters, either.) In fact, their whole family is fraught with unresolved conflicts. Then Claude's uncle is arrested on a felony charge, and everyone rallies round. Ruby's mother Jewel and flirtatious sister Rose (Claude's ex-girlfriend) even fly in from Tennessee; but, far from being a source of support, Jewel seems only to want to break up Ruby and Claude.

Following a series of drug deals and murders, three criminals -- Fantasia, Ray Malcolm and Pluto -- travel from Los Angeles to Houston, finally arriving in a small Arkansas town to go into hiding. Two detectives from the LAPD, who are already on the case, contact the town's sheriff, Dale Dixon, to alert him of the fugitives' presence in the area. Underestimating Dixon, the criminals have no idea what they are about to face.

Karl Childers, a mentally disabled man, has been in the custody of the state mental hospital since the age of 12 for killing his mother and her lover. Although thoroughly institutionalized, he is deemed fit to be released into the outside world.

Annie Wilson, young widow and mother of three, makes her living foretelling others' futures⁠—though her own has become cloudier than even she can see. Threatened by a client's violent husband and plagued by visions of a missing local woman, Annie finds herself pulled into a thicket of lies and deception in which her extraordinary gift may ultimately get her killed.