A young woman's husband has been imprisoned for a crime he didn't commit. In order to be near him to try to help him get his sentence overturned, she moves into a boardinghouse near the prison whose residents are the wives of inmates.

Set in the early 20th century, the film follows a game warden who arrives in Florida to enforce conservation laws. He soon finds himself pitted against Cottonmouth, the leader of a fierce group of bird poachers.

Annie (Ann Gillis), an orphan, (based on Harold Gray's comic strip but who is at no point in the film called 'Little Orphan Annie), is befriended by a fight manager, 'Pop' Corrigan (J. Farrell MacDonald). She brings him Johnny Adams (Robert Kent), a promising prizefighter. Annie gets the people of the neighborhood to finance his training. But on the night of Johnny's big fight, a gambling syndicate locks him in a gymnasium and it appears the neighborhood folks will lose their investment.