An anonymous love letter left in Michael Ryan's locker on the last day of school wreaks havoc on his life and the lives of everyone who comes in contact with it.

The vampire Angel, cursed with a soul, moves to Los Angeles and aids people with supernatural-related problems while questing for his own redemption. A spin-off from Buffy the Vampire Slayer.

New vampires Spike and Drusilla come to town along with the new slayer, Kendra Young, who was activated as a result of Buffy's brief death in the season one finale. Xander becomes involved with Cordelia, while Willow becomes involved with witchcraft and Daniel "Oz" Osbourne becomes a werewolf after being bitten by a young cousin who just happens to be a werewolf. Buffy and the vampire Angel develop a relationship over the course of the season, but Angel's dark past as the evil and sadistic Angelus threatens to destroy Buffy and the world.

After Portland homicide detective Nick Burkhardt discovers he's descended from an elite line of criminal profilers known as "Grimms," he increasingly finds his responsibilities as a detective at odds with his new responsibilities as a Grimm.