Johnnie learns crime from petty thug Frank Wilson. When Wilson kills a pawnbroker with a gun stolen from Johnnie's sister Madge's fiance Fred Burke, Fred goes to Sing Sing's death house. Wilson uses all the pressure can to keep Johnnie silent, even after he and Johnnie themselves wind up in the big house.

A boxer flees, believing he has committed a murder while he was drunk.

A paroled convict's efforts to improve conditions at a boys' reform school alarm the school's corrupt warden, who has been embezzling funds from the institution. He hatches a plan to derail the reformed convict's efforts and have him sent back to prison, and part of that scheme involves cracking down hard on the reform school's inmates.

In the slums, teenager Frankie Warren hangs out with a rowdy gang who one day knock him out in a fight. In court, the boys refuse to reveal who struck the knockout blow, and all are subsequently sentenced to a reformatory, cruelly run by two corrupt guards. New deputy commissioner Mark Braden arrives determined to change things, but despite the help of Frankie's sister, Mark's reform plans -- and Frankie's future -- may be sabotaged from within.

Embittered after serving time for a burglary he did not commit, Joe Bell is soon back in jail, on a prison farm. His love for the foreman's daughter leads to a fight between them, leading to the older man's death due to a weak heart. Joe and Mabel go on the run as he thinks no-one would believe a nobody like him.

Childhood chums Rocky Sullivan and Jerry Connelly grow up on opposite sides of the fence: Rocky matures into a prominent gangster, while Jerry becomes a priest, tending to the needs of his old tenement neighborhood.