Shaun Murphy, a young autistic surgeon with savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Dr. Shaun Murphy continues to use his extraordinary medical gifts at St. Bonaventure Hospital’s surgical unit. As his friendships deepen, Shaun tackles the world of dating for the first time and continues to work harder than he ever has before.