Two nuns arrive unannounced in the small New England town of Bethlehem, where they recruit various townspeople to help them build a children's hospital.

Jubal Troop is a cowboy who is found in a weakened condition, without a horse. He is given shelter at Shep Horgan's large ranch, where he quickly makes an enemy in foreman Pinky, a cattleman who accuses Jubal of carrying the smell of sheep.

Pinky, a light skinned black woman, returns to her grandmother's house in the South after graduating from a Northern nursing school. Pinky tells her grandmother that she has been "passing" for white while at school in the North. In addition, she has fallen in love with a young white doctor, who knows nothing about her black heritage.

A gambler faces deportation when he gets mixed up with murder.

A man tries to find a son he gave up for adoption years ago.

In the late 1890s, the ambitious, innocent Carrie arrives in Chicago’s South Side and stays with her nagging, dullish married sister. She then runs for help to traveling salesman Charles Drouet. She soon becomes his mistress, but falls in love with married restaurant manager George Hurstwood.

After escaping from jail, outlaw Wes McQueen is convinced by his old partner in crime to do one last heist.

A successful, unorthodox doctor befriends a young woman with suicidal ideations due to her pregnancy by her ex, a military reservist killed in action.

Cleve Marshall, an assistant district attorney, falls for Thelma Jordon, a mysterious woman with a troubled past. When Thelma becomes a suspect in her aunt's murder, Cleve tries to clear her name.

A former Union Army officer plans to sell out to Anchor Ranch and move east with his fiancée, but the low price offered by Anchor's crippled owner and the outfit's bullying tactics make him reconsider. When one of his hands is murdered he decides to stay and fight, utilizing his war experience. Not all is well at Anchor with the owner's wife carrying on with his brother who also has a Mexican woman in town.