A serpentine day in the life of ten seemingly disparate women: a porn star, a flight attendant, a psychiatrist, a masseuse, a bartender, a pair of call girls, etc. All of them with one crucial thing in common. Trouble.

The newly married Elizabeth arrives with her new husband, the scientist Henry, at a magnificent house. He tells her that she can do there anything she pleases, except to enter a certain closed room.