My Best Friend is the outrageous story of two men, friends since childhood, who have spent their lives tormenting one another. It is only when Constantinos discovers Alekos in bed with his wife that their friendship and their respective marriages finally collapse into a death spiral of sex, deceit and irrepressible humor. As events unfold another deception, one concealed by both men's wives, opens the door to incredible erotic intrigue.

Three separate narratives each following a love story between a foreigner and a Greek. Each story represents a different generation falling in love during a time of socioeconomic turmoil that dominates Southern Europe as a whole, only to connect as a single story in the end.

A musician goes to lead a festival on a scenic island, where he begins an unexpected romance and finds himself entwined in other people's problems.