After the death of his wife, world-class neurosurgeon Dr. Andrew Brown leaves Manhattan and moves his family to the small town of Everwood, Colorado. There he becomes a small-town doctor and learns parenting on the fly as he raises his talented but resentful 15-year-old son Ephram and his 9-year-old daughter Delia.

Ten years after she was separated from her family, an eighteen-year-old orphan with vague memories of the past sets out to Paris in hopes of reuniting with her grandmother. She is accompanied by two con men, who intend to pass her off as the Grand Duchess Anastasia to the Dowager Empress for a reward.

When struggling, out of work actor Michael Dorsey secretly adopts a female alter ego – Dorothy Michaels – in order to land a part in a daytime drama, he unwittingly becomes a feminist icon and ends up in a romantic pickle.

At an elite, old-fashioned boarding school in New England, a passionate English teacher inspires his students to rebel against convention and seize the potential of every day, courting the disdain of the stern headmaster.