In the chambers of the Edo harem, two newcomers uncover political intrigue, rivalry and a vengeful spirit only one traveling medicine seller can vanquish.

Set in a future world. Japan has created a great medical technology that controls ethics, health, and social interaction to create a perfect world. Three young girls attempt to stand up to this by committing suicide, but it doesn't work. Years later, Tuan, one of the girls who attempted suicide must prevent a crisis that threatens this "perfect" world.

The story takes place in 19th century Europe, and revolves around John Watson. He is scouted by the government to become a secret agent. However, Watson lives in a world where "Frankensteins"—human corpses that are re-purposed with a false soul in order to use them as laborers—are used to improve industrial development.