Flight 7500 departs Los Angeles International Airport bound for Tokyo. As the overnight flight makes its way over the Pacific Ocean during its ten-hour course, the passengers encounter what appears to be a supernatural force in the cabin.

Four Navy SEALs on a covert mission to neutralize a high-level Taliban operative must make an impossible moral decision in the mountains of Afghanistan that leads them into an enemy ambush. As they confront unthinkable odds, the SEALs must find reserves of strength and resilience to fight to the finish.

All the couples are back for a wedding in Las Vegas, but plans for a romantic weekend go awry when their various misadventures get them into some compromising situations that threaten to derail the big event.