Rusty Sabich is a deputy prosecutor engaged in an obsessive affair with a coworker who is murdered. Soon after, he's accused of the crime. And his fight to clear his name becomes a whirlpool of lies and hidden passions.

A law student's theory about the recent deaths of two Supreme Court justices embroils her in a far-reaching web of murder, corruption, and greed.

Stingo, a young writer, moves to Brooklyn in 1947 to begin work on his first novel. As he becomes friendly with Sophie and her lover Nathan, he learns that she is a Holocaust survivor. Flashbacks reveal her harrowing story, from pre-war prosperity to Auschwitz. In the present, Sophie and Nathan's relationship increasingly unravels as Stingo grows closer to Sophie and Nathan's fragile mental state becomes ever more apparent.