Two people meet each other after missing the last train home, leading to a beautiful relationship over five years.

While the Second World War rages, the teenage Mahito, haunted by his mother's tragic death, is relocated from Tokyo to the serene rural home of his new stepmother Natsuko, a woman who bears a striking resemblance to the boy's mother. As he tries to adjust, this strange new world grows even stranger following the appearance of a persistent gray heron, who perplexes and bedevils Mahito, dubbing him the "long-awaited one."

Set in a small restaurant in the corner of a shopping district. The unusual eatery is only open after midnight, and its standard menu consists of just a single choice. However, the customers still come for the amusing chatter and the proprietor's willingness to cook any dish that they request. This drama depicts the lives of the restaurant's patrons, including a yakuza, an unsuccessful actor, a group of office ladies, a newspaper delivery boy, and a stripper.

Ashitaka, a prince of the disappearing Emishi people, is cursed by a demonized boar god and must journey to the west to find a cure. Along the way, he encounters San, a young human woman fighting to protect the forest, and Lady Eboshi, who is trying to destroy it. Ashitaka must find a way to bring balance to this conflict.