It's 1960 and change is in the air. Looking to hone her act, Midge finds a gig with total creative freedom. But her commitment to her craft—and the places it takes her—creates a rift between her and the family and friends around her.

After Midge's triumph at the Gaslight, the fallout from her takedown of Sophie Lennon looms large, making her climb up the comedy ladder more challenging than ever. As the actual grind of being a comic begins to take its toll on Midge, the pressure to come clean to her family weighs on her - especially as her choices have a ripple effect on everyone around her.