A group of friends race their high-powered cars up and down a dangerous and deadly mountain road known as Mulholland Drive to see who can claim the title of "King of the Hill."

An unlucky woman’s mother is murdered by a scarf-wielding killer named Silk, leaving the woman injured, traumatised and suffering from amnesia. She’s committed to a mental institution, where Silk follows her, looking for the papers he was trying to get from her mother. And Silk’s only the beginning of her problems, since the asylum is run by a mad doctor, performing experiments in chemical lobotomies!