The Cortez brothers rob a bank and flee beyond the Mexican border. On their trail are various people, each for a different reason: Sheriff Fulton is sent by the robbed bank to recuperate the money; Django, a head-hunter, is after them for the reward money; Pickwick is after a saddle stolen from him by the Cortez brothers; Pedro and Dolores, saloon owners, also would like to have the loot.

Django is on the trail of some renegade outlaws who raped and killed his wife. En route, he rescues a horse thief from an impromptu hanging. He discovers the man knows who committed the murder. The men team up and head west for revenge.

Luigi Batzella directed this spaghetti western under the pseudonym "Paolo Solvay." Gioffredo Scarciofolo stars (using his standard alias, "Jeff Cameron") as Tom Carter, whose brother was murdered and robbed by the evil Ringo Brown (William Mayor) shortly after taking all his money out of the bank to marry Cora (Krista Nell), a local saloon girl. Tom is suspicious of Cora, but she helps him unmask the real killer.