In 1972, the Apollo 17 mission discovered a hypergate to Mars on the surface of the moon. Soon a war breaks out between Earth and Mars, and Martian soldiers begin to descend from the sky, riding steel giants, intent on exterminating humanity.

Shinichi Chiaki is a first class musician whose dream is to play among the elites in Europe. Coming from a distinguished family, he is an infamous perfectionist; not only is he highly critical of himself, but of others as well. The only thing stopping Chiaki from leaving for Europe is his fear of flying. As a result, he's grounded in Japan.

During his 4th year at Japan's top music university, Chiaki happens to meet Noda Megumi—or as she refers to herself, Nodame. On the surface, she seems to be an unkempt girl with no direction in life. However, when Chiaki hears Nodame play the piano for the first time, he is in awe at the kind of music she plays. To Chiaki's dismay, Nodame moves into the apartment next to his and finds out that she is head-over-heels in love with him.

应届大学毕业生森美咲（早见沙织 饰），因为父母早年过世，现和经营面包店的姐姐和姐夫一家生活。而她现在正在美国白宫前参观旅游。一切都很正常，直到咲她被卷入一场冲突事件，所幸被解救下来，而拯救他的英雄却是个一丝不挂，全身上下只有手机一件物品的奇怪男子。而该男子不幸还失忆了，只知道他的名字是泷泽朗（木村良平 饰）。而这个叫做朗的奇异男子只是所有事情的一个序幕。咲的世界观至此被颠覆，一堆疑问在她面前亟待解决。这个男子究竟是谁？那个手机里的巨额财产是怎么一回事？这些谜底随着故事的进展一一被揭晓……
本剧是日本富士电视台noitaminA的第一部原创动画。担任其人设的则是《蜂蜜与四叶草》的作者羽海野千花。

因为感觉到自己欠缺了某种制胜的关键因素，“不幸的天才击球手”儿岛弘道，与教练木野崎、投手中根一起，前往冲绳进行特训，在那里他们碰见了了号称赌博棒球从无败迹的谜样的男人——渡久地东亚。
对于东亚的赌球行为深感愤慨的儿岛，提出与东亚进行一场名为"ONE OUTS"比赛——即击球手与投球手的双人对决。结果，身为天才职业击球手的儿岛，竟然惨败给了只有“三流投手”水平的东亚，同时他也深深领略到了这个男人的可怕之处。
经过一段时间的山中修行，儿岛提出要以自己的职业生涯来赌东亚的右手，与东亚再赛一局。第二战中，拼尽全力的儿岛利用规则的漏洞，终于赢了未尝一败的东亚。
“用那边的球棒，打断我的右手吧”，东亚按照约定伸出了自己的右手，却被儿岛紧紧握住：“谁说要打断它？我只说过要你的右手！来职业棒球的世界吧！”
因为儿岛的关系，以投手身份进入LYCAONS球队的东亚，与球队董事、（株）彩珠组会长彩川桓雄定下了每出局一人得到五百万报酬，每失一分支付五千万罚金的疯狂赌约。
只投直球，球速不过120公里的渡久地东亚，到底会给万年B级的弱旅LYCAONS带来怎样的奇迹呢？
以棒球的世界为舞台，上演着超级智力的对决！在ONE OUTS的游戏中无往而不胜的男人——渡久地东亚，直觉？实力？魔术？投出无人能接住的球的秘密到底是——？
【STAFF】
原作：甲斐谷忍（集英社 BJ YJC刊）
监督：佐藤雄三
系列构成：高屋敷英夫
人物设定：梅原隆弘
音乐：松本晃彦
音响监督：本田保則
动画制作：Mad House

In the year 2029, the barriers of our world have been broken down by the net and by cybernetics, but this brings new vulnerability to humans in the form of brain-hacking. When a highly-wanted hacker known as 'The Puppetmaster' begins involving them in politics, Section 9, a group of cybernetically enhanced cops, are called in to investigate and stop the Puppetmaster.